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Population structure of Neisseria meningitidis ST-9493 identified in Colombian isolates

Zonia Katerin Alarcon1, Diego Prada1, Jean Marc Gabastou2

  • 1Grupo de Microbiología, Instituto Nacional de Salud (INS), Bogotá, Colombia.

Enfermedades Infecciosas Y Microbiologia Clinica (English Ed.)
|January 21, 2023
PubMed
Abstract

Insights

Colombian Neisseria meningitidis isolates (ST-9493) form a distinct clonal group capable of causing invasive disease. This study characterized their genetic makeup and identified traits linked to endemic and epidemic spread.

Area of Science:

  • Microbiology
  • Genomics
  • Epidemiology

Background:

  • Neisseria meningitidis causes invasive infections with high mortality.
  • Emerging clonal groups pose a significant public health threat.

Purpose of the Study:

  • Describe the population structure of Colombian invasive Neisseria meningitidis isolates with ST-9493.
  • Characterize the genotypic and phenotypic traits of this potentially emerging clonal group.

Main Methods:

  • Whole-genome sequencing of 34 invasive serogroup B isolates.
  • Phylogenetic analysis to establish clonal relationships.
  • Identification of key alleles and peptide variants (porA, porB, fHbp, NHBA, FetA).

Main Results:

  • ST-9493 isolates form two main phylogenetic clades, linked to outbreaks or endemic disease.
  • Frequent alleles/peptides identified: porA 17, porB 44, fHbp 2.24, NHBA 10, FetA F5-17.
  • Most isolates exhibited susceptibility to evaluated antibiotics.

Conclusions:

  • Neisseria meningitidis ST-9493 represents an autochthonous clonal group in Colombia.
  • This group possesses population dynamics enabling endemic and epidemic disease.
  • Understanding ST-9493 is crucial for controlling meningococcal disease in the region.
Keywords:
ClonCloneMultilocus sequence typingNeisseria meningitidisSecuenciación de genoma completoSerogroup BSerogrupo BTipificación multilocus de secuenciasWhole genome sequencing

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