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Evaluation of the relationship between migraine and psoriasis: a case-control study
Mohamad Sarkhani1, Majid Rostami Mogaddam2, Ghasem Fattahzadeh-Ardalani3
1Students Research Committee, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
Anais Brasileiros De Dermatologia
|January 21, 2023
Summary
Psoriasis patients have a significantly higher risk of developing migraine, especially migraine with aura. Increased psoriasis severity and psoriatic arthritis (PsA) further elevate this risk.
Area of Science:
- Dermatology and Neurology
- Clinical Research
- Epidemiology
Background:
- Limited data exists on the association between psoriasis and migraine.
- Understanding this comorbidity is crucial for patient care.
Purpose of the Study:
- To investigate the relationship between migraine and psoriasis.
- To compare migraine prevalence in psoriasis patients versus controls.
Main Methods:
- A case-control study involving 312 psoriasis patients and 312 matched controls.
- Patients were categorized into four subgroups based on psoriasis and migraine diagnosis.
- Characteristics of migraine and psoriasis were compared across subgroups.
Main Results:
- Psoriasis patients showed a significantly higher likelihood of having migraine (OR = 2.789).
- Migraine with aura was more prevalent in psoriasis patients with migraine.
- Higher psoriasis severity and the presence of psoriatic arthritis (PsA) were associated with increased migraine risk.
Conclusions:
- Psoriasis patients face a substantially elevated risk of migraine compared to the general population.
- Severe psoriasis and co-existing PsA significantly increase migraine risk.
- The study highlights a strong association between psoriasis and migraine, particularly migraine with aura.
