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Related Experiment Video

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Photomodulated Extrusion as a Localized Endovascular Hydrogel Deposition Method.

Yuta Dobashi1,2, Jerry C Ku1,2,3, Joel Ramjist2

  • 1Institute of Medical Science, University of Toronto, Toronto, Ontario, M5S 1A1, Canada.

Advanced Healthcare Materials
|January 22, 2023
PubMed
Summary

A new photomodulated hydrogel injection technique offers precise control over embolization in diverse blood vessels. This advanced method also enables sustained drug delivery, improving therapeutic outcomes in endovascular treatments.

Keywords:
drug deliveryendovascular embolizationhydrogelsshear thinning

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Interventional Radiology

Background:

  • Minimally invasive endovascular embolization treats diverse conditions but faces limitations with current devices.
  • Existing techniques struggle with varied vasculature and can cause complications like migration and remodeling.
  • Current embolization agents offer limited therapeutic functions beyond flow control, such as drug delivery.

Purpose of the Study:

  • To develop and demonstrate a novel in situ microcatheter-based photomodulated extrusion approach for endovascular embolization.
  • To dynamically tune injectable hydrogel properties for optimal performance in various hemodynamic environments and vascular morphologies.
  • To establish a versatile platform for therapeutic delivery via endovascular means.

Main Methods:

  • Utilized a shear-thinning and photoactivated poly(ethylene glycol diacrylate)-nanosilicate (PEGDA-nSi) hydrogel.
  • Employed microcatheter-based photomodulated extrusion with controlled photokinetics and device configurations.
  • Demonstrated embolization in diverse vasculature, including high-flow vessels and capillary shunts.
  • Developed a core-shell hydrogel extrusion for sustained doxorubicin release.

Main Results:

  • Successfully demonstrated real-time photomodulation of hydrogel viscosity and modulus for precise embolization.
  • Achieved effective embolization across a range of challenging vascular anatomies.
  • Showcased the hydrogel's capability for sustained drug release compared to unencapsulated drugs.
  • Validated the adaptability of the technique for both embolization and targeted therapeutic delivery.

Conclusions:

  • The photomodulated extrusion approach offers a significant advancement in endovascular embolization.
  • This novel technique provides dynamic control over material properties, optimizing treatment for individual vascular conditions.
  • The platform demonstrates potential for enhanced therapeutic efficacy through sustained drug delivery.
  • This method addresses limitations of current embolization agents and expands therapeutic possibilities in interventional medicine.