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Clinical course and outcome of Covid-19 in patients with myasthenia gravis

Gonulden Aktoz1, Cavit Boz2, Serap Zengin2

  • 1Faculty of Health Sciences, Infectious Disease and Clinical Microbiology, Avrasya University, Trabzon, Turkey.

Neurological Research
|January 22, 2023
PubMed
Abstract

Insights

Patients with myasthenia gravis (MG) and high MG-ADL scores or a history of myasthenic crisis face a higher risk of severe COVID-19. Most MG patients recover well from COVID-19.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Immunology

Background:

  • Myasthenia gravis (MG) is a chronic autoimmune neuromuscular disease.
  • Understanding COVID-19 outcomes in MG patients is crucial for clinical management.
  • Factors influencing COVID-19 severity in MG require further investigation.

Purpose of the Study:

  • To analyze COVID-19 prognosis and outcomes in patients with myasthenia gravis.
  • To identify factors associated with severe COVID-19 in MG patients.

Main Methods:

  • Single-center observational study.
  • Inclusion of 275 MG patient records.
  • Univariate and multivariate analyses to identify risk factors for severe COVID-19.

Main Results:

  • 29.8% of MG patients had concurrent COVID-19.
  • Severe COVID-19 occurred in 17.07% of cases, with 4.9% mortality.
  • High pre-COVID MG-ADL scores and history of myasthenic crisis were associated with severe COVID-19.

Conclusions:

  • Most myasthenia gravis patients experience good recovery from COVID-19.
  • High MG-ADL scores and a history of myasthenic crisis are key risk factors for severe COVID-19.
  • MG treatment type did not independently affect COVID-19 severity.
Keywords:
Covid-19Myasthenia graviscoronavirus

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