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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
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miRNAs role in bladder cancer pathogenesis and targeted therapy: Signaling pathways interplay - A review

Hesham A El-Mahdy1, Elsayed G E Elsakka1, Ahmed A El-Husseiny2

  • 1Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City 11231, Cairo, Egypt.

Pathology, Research and Practice
|January 22, 2023
PubMed

Insights

MicroRNAs (miRNAs) play a crucial role in bladder cancer (BC) by regulating cellular events. Dysregulated miRNAs are linked to BC progression and patient outcomes, highlighting their diagnostic and therapeutic potential.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Bladder cancer (BC) is a significant health concern globally.
  • Current BC care focuses on improving diagnosis, prognosis, and treatment.
  • MicroRNAs (miRNAs) are key regulators of gene expression with potential roles in cancer.

Purpose of the Study:

  • To review recent advances in understanding the role of miRNAs in bladder cancer.
  • To discuss the involvement of miRNAs in BC pathogenesis and therapy.
  • To explore the clinical applications of miRNAs in BC diagnosis, prognosis, and treatment.

Main Methods:

  • Literature review of studies investigating miRNAs in bladder cancer.
  • Analysis of miRNA dysregulation in BC development and progression.
  • Examination of current and emerging clinical applications of miRNAs in BC.

Main Results:

  • miRNA dysregulation (upregulation or downregulation) is common in BC.
  • Altered miRNAs are associated with key cancer hallmarks like proliferation, apoptosis, and metastasis.
  • Specific miRNAs correlate with tumor characteristics and patient survival.
  • miRNAs show promise as diagnostic biomarkers and therapeutic targets for BC.

Conclusions:

  • miRNAs are integral to bladder cancer pathogenesis and progression.
  • miRNAs offer potential for improved BC diagnosis, prognosis, and targeted therapies.
  • Further research is needed to fully realize the clinical utility of miRNAs in BC management.
Keywords:
BiogenesisBladder cancer (BC)Oncogenic miRNAsPathogenesisTumor suppressor (TS) miRNAs

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