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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
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Contemporary Systemic Therapies in Urothelial Carcinoma

Jj H Zhang1, Savannah L Starr2, Karim Chamie1

  • 1Department of Urology, UCLA Medical Center, Los Angeles, CA.

Urology
|January 22, 2023
PubMed

Insights

Novel systemic therapies, including immune checkpoint inhibitors (ICIs) and antibody-drug conjugates (ADCs), offer new hope for muscle-invasive bladder cancer (MIBC) and advanced urothelial carcinoma (UC). These treatments show promise in various settings, including neoadjuvant and adjuvant therapy.

Area of Science:

  • Oncology
  • Urothelial Carcinomas
  • Systemic Therapy

Background:

  • Systemic therapy options for muscle-invasive bladder cancer (MIBC) and locally advanced/metastatic urothelial carcinoma (la/mUC) were limited, especially for cisplatin-ineligible patients or after chemotherapy progression.
  • Emerging data indicates novel systemic therapies are effective in the la/mUC setting and are showing potential in neoadjuvant and adjuvant treatment.

Purpose of the Study:

  • To review the current landscape of contemporary systemic therapies for urothelial carcinoma (UC).
  • To discuss the application of immune checkpoint inhibitors (ICIs), antibody-drug conjugates (ADCs), and targeted therapies in UC.
  • To explore the potential of combination therapies for enhanced treatment response.

Main Methods:

  • Narrative review of contemporary systemic therapies for urothelial carcinoma.
  • Examination of immune checkpoint inhibitors (ICIs).
  • Analysis of antibody-drug conjugates (ADCs) and targeted therapies.

Main Results:

  • Novel systemic therapies represent a significant advancement in UC treatment.
  • ICIs, ADCs, and targeted therapies are demonstrating efficacy in la/mUC.
  • Evidence suggests these therapies are valuable in neoadjuvant and adjuvant settings.

Conclusions:

  • Contemporary systemic therapies have transformed treatment paradigms for UC.
  • Immune checkpoint inhibitors, antibody-drug conjugates, and targeted therapies are key advancements.
  • Combination strategies may further improve durable responses in urothelial carcinoma.

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