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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Metastasis02:30

Metastasis

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

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Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
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Tumor Progression02:07

Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Related Experiment Video

Updated: Aug 13, 2025

Assessing Tumor Microenvironment of Metastasis Doorway-Mediated Vascular Permeability Associated with Cancer Cell Dissemination using Intravital Imaging and Fixed Tissue Analysis
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Assessing Tumor Microenvironment of Metastasis Doorway-Mediated Vascular Permeability Associated with Cancer Cell Dissemination using Intravital Imaging and Fixed Tissue Analysis

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Pericytes in the tumor microenvironment.

Zhongyi Jiang1, Jing Zhou1, Luohong Li1

  • 1NHC Key Laboratory of Carcinogenesis, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, 410013, China; Cancer Research Institute, Basic School of Medicine, Central South University, Changsha, Hunan, 410078, China.

Cancer Letters
|January 22, 2023
PubMed
Summary
This summary is machine-generated.

Pericytes are crucial mural cells in the tumor microenvironment (TME), influencing cancer growth and metastasis. Understanding pericyte roles offers new avenues for tumor treatment and prevention strategies.

Keywords:
Epithelial-mesenchymal transitionPericytesTumor microenvironmentTumor therapyTumor-associated macrophages

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Area of Science:

  • Oncology
  • Cell Biology
  • Microcirculation Research

Background:

  • Pericytes are mural cells integral to capillary structure and function, regulating vasomotor activity and tissue microcirculation.
  • Pericytes are increasingly recognized as significant components within the tumor microenvironment (TME).
  • Their interactions within the TME include forming pre-metastatic niches, promoting cancer cell proliferation and drug resistance, and influencing immune cell polarization.

Purpose of the Study:

  • To review the multifaceted roles of pericytes within the tumor microenvironment (TME).
  • To explore the dynamic interactions between pericytes and various tumor components.
  • To discuss the implications of pericyte function for cancer treatment and prevention strategies.

Main Methods:

  • This study is a comprehensive review of existing literature.
  • It synthesizes findings on pericyte biology and their involvement in cancer.
  • The review analyzes the impact of TME changes on pericyte characteristics.

Main Results:

  • Pericyte detachment from endothelial cells in the TME aids tumor cell invasion and metastasis.
  • Pericytes contribute to tumor angiogenesis through paracrine signaling and basement membrane modification.
  • Changes in pericyte number, phenotype, and markers reflect TME alterations.

Conclusions:

  • Pericytes play a pivotal role in tumor progression, angiogenesis, and metastasis.
  • Targeting pericyte-TME interactions presents potential therapeutic strategies for cancer.
  • Further understanding of pericyte functions can guide the development of novel anti-cancer treatments.