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Related Experiment Video

Updated: Aug 13, 2025

Author Spotlight: Understanding Chronic Lung Diseases Using 3D Printed Phototunable Hydrogels
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3D printed tissue models: From hydrogels to biomedical applications.

Francesca Cadamuro1, Francesco Nicotra1, Laura Russo2

  • 1University of Milano-Bicocca, Department of Biotechnology and Biosciences, Piazza della Scienza 2, 20126 Milano, Italy.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|January 22, 2023
PubMed
Summary

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This review explores extracellular matrix (ECM) properties and how 3D printing and bioprinting can create advanced tissue mimics. These bio-inks are functionalized for bio-responsive and bio-instructive applications.

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Understanding extracellular matrix (ECM) properties is crucial for developing advanced tissue and organ constructs.
  • Morphological and biochemical ECM characteristics vary across tissues, organs, and health/pathological conditions.

Approach:

  • This review examines how ECM properties change in diverse biological contexts.
  • It details the use of 3D printing and bioprinting technologies to fabricate ECM mimics.
  • The review classifies natural and synthetic polymeric materials used as hydrogel inks for these printing techniques.

Key Points:

  • ECM mimics are crucial for developing advanced tissue constructs.
  • 3D printing and bioprinting offer precise control over ECM mimic fabrication.
Keywords:
3D bioprinting3D tissue modelsECM mimicsbiomaterialsclick chemistry

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  • Functionalization of hydrogel inks with signaling molecules creates bio-responsive and instructive materials.

    • Conclusions:

    • Advanced ECM mimics can be engineered using 3D printing and bioprinting.
    • Tailored bio-inks with specific material and signaling properties are key for regenerative medicine applications.