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Heart transplantation for COVID-19 myopathy in the United States

George Gill1, Amy Roach1, Georgina Rowe1

  • 1Department of Cardiac Surgery, Cedars-Sinai Medical Center, Los Angeles, CA.

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
|January 22, 2023
PubMed

Insights

Heart transplantation for COVID-19 myocarditis is rare but shows promising results. Patients with COVID-19 associated cardiomyopathy had excellent graft survival post-transplant, suggesting it

Area of Science:

  • Cardiology
  • Transplantation Immunology
  • Infectious Diseases

Background:

  • Limited data exists on heart transplantation for coronavirus disease 2019 (COVID-19) associated cardiomyopathy.
  • Case reports are the primary source of information.

Purpose of the Study:

  • To investigate the characteristics and outcomes of heart transplant recipients with COVID-19 myocarditis.
  • To compare outcomes with non-COVID-19 myocarditis patients.

Main Methods:

  • Retrospective analysis of the United Network for Organ Sharing database.
  • Inclusion of adult heart transplant recipients from July 2020 to May 2022.
  • Comparison of 12 COVID-19 myocarditis patients with 98 non-COVID-19 myocarditis patients.

Main Results:

  • Only 0.2% of heart transplants were for COVID-19 myocarditis.
  • COVID-19 patients had 100% survival free from graft failure at a median of 257 days.
  • Non-COVID-19 patients had 88.5% survival free from graft failure.

Conclusions:

  • Heart transplantation for COVID-19 cardiomyopathy is infrequently performed in the U.S.
  • Early outcomes for select COVID-19 myocarditis patients undergoing heart transplantation appear favorable.
  • Transplantation is a viable option for severe COVID-19 associated cardiomyopathy.

Keywords:
COVID-19cardiac surgerycritical careheart failureheart transplant

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