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Upregulated DNA Damage-Linked Biomarkers in Parkinson's Disease Model Mice
Fei Zeng1,2, Karsten Parker2, Yanqiang Zhan1,2
1Department of Neurology, Renmin Hospital of the Wuhan University, Wuhan, China.
ASN Neuro
|January 23, 2023
Abstract
Summary Statement:
The present study examined expression of DNA damage markers in VMAT2 Lo PD model mice. The results demonstrate there is a significant increase in these DNA damage markers mostly in the brain regions of 18- and 23-month-old model mice, indicating oxidative stress-induced DNA lesion is an important pathologic feature of this mouse model.
