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Assessment of Circulating CCR6 Level in Acute Myocardial Infarction and its Association with Disease Severity

Amira Mohamed Noureldin Abdelrahman1, Amal Elmahdy Mohamed1, Ahmed Mahmoud Bendary2

  • 1Department of Clinical and Chemical Pathology, Faculty of Medicine, Benha University, Egypt.

Cardiovascular & Hematological Agents in Medicinal Chemistry
|January 23, 2023
PubMed

Insights

Higher expression of chemokine receptor CCR6 (Ccr6) on lymphocytes was found in acute myocardial infarction (AMI) patients. This finding suggests CCR6 may be a biomarker for AMI severity and coronary artery disease progression.

Area of Science:

  • Cardiovascular Medicine
  • Immunology
  • Biomarker Discovery

Background:

  • Acute myocardial infarction (AMI) involves systemic and intraplaque inflammation, often triggered by coronary artery thrombosis.
  • The G-protein-coupled chemokine receptor (Ccr6) is expressed on leukocytes within atherosclerotic plaques and acts as an inflammation mediator.

Purpose of the Study:

  • To quantify CCR6 lymphocyte expression in AMI patients.
  • To investigate the association between CCR6 expression and AMI severity using the Gensini scoring system.

Main Methods:

  • Flow cytometry was used to measure circulating CCR6+ lymphocytes in 25 AMI patients and 25 controls.
  • Multivariate logistic regression analysis was employed to assess the predictive value of CCR6 for AMI.

Main Results:

  • AMI patients exhibited a significantly higher percentage of CCR6+ lymphocytes compared to controls.
  • CCR6 expression positively correlated with the Gensini score (GS), indicating a link to coronary artery disease (CAD) severity.

Conclusions:

  • CCR6 is an independent biomarker for AMI.
  • CCR6 may facilitate T lymphocyte recruitment, potentially destabilizing coronary lesions.
Abstract

Keywords:
CCR6acute myocardial infarctionatherosclerosisgensini scorelogistic regression analysislymphocyte

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