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Predictive value of inflammatory and coagulation biomarkers for venous thromboembolism in COVID-19 patients

Marta Hojker1,2, Jure Tršan2,3, Uroš Tršan2

  • 1University Medical Centre Ljubljana, Department of Orthopaedic Surgery, Ljubljana, Slovenia.

Clinical Hemorheology and Microcirculation
|January 23, 2023
PubMed

Insights

D-dimer is a valuable predictor of venous thromboembolism (VTE) in COVID-19 patients, showing strong correlation with VTE risk. Higher D-dimer cut-off values are recommended for accurate VTE prediction in this population.

Area of Science:

  • Medical Research
  • Hematology
  • Infectious Diseases

Background:

  • Conflicting data exists on the predictive value of coagulation markers for venous thromboembolism (VTE) in COVID-19 patients.
  • Investigating these markers is crucial for managing COVID-19 complications.

Purpose of the Study:

  • To determine the correlation between various biomarkers and VTE in hospitalized COVID-19 patients.
  • To evaluate the predictive capability of D-dimer for VTE development.

Main Methods:

  • Collected complete blood count, inflammatory, and coagulation biomarkers at admission.
  • Defined VTE as diagnosed pulmonary embolism or deep vein thrombosis.
  • Utilized Pearson prediction models and ROC curve analysis to assess D-dimer's predictive value.

Main Results:

  • 1651 participants were analyzed, with 111 cases of VTE identified.
  • Neutrophil-lymphocyte ratio and D-dimer levels were significantly associated with VTE.
  • D-dimer demonstrated strong predictive value for VTE (ROC area 0.85) with an optimal cut-off of 2677μg/L.

Conclusions:

  • D-dimer exhibits the highest predictive value for VTE among coagulation biomarkers in COVID-19 patients.
  • Recommended higher D-dimer cut-off values for improved VTE prediction in COVID-19 cases.
Abstract

Keywords:
COVID-19D-dimercoagulation biomarkersinflammatory biomarkersneutrophil-lymphocyte ratiovenous thromboembolism

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