Related Experiment Video
Updated: Aug 13, 2025
08:19
Isolation of Leukocytes from the Human Maternal-fetal Interface
Published on: May 21, 2015
16.1K
Pregnancy-induced leukocytosis: A case report
Xi Wang1, Yang-Yang Zhang1, Yang Xu2
1Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing 100034, China.
World Journal of Clinical Cases
|January 23, 2023
Summary
Pregnancy-induced leukocytosis, a rare condition with elevated white blood cell counts, typically resolves after childbirth. This case highlights its association with immunoregulation, suggesting delivery as a key treatment for complicated pregnancies.
Area of Science:
- Obstetrics and Gynecology
- Hematology
Background:
- Pregnancy involves significant physiological changes, including common leukocytosis (elevated white blood cells), particularly neutrophilia in the third trimester.
- Non-congenital leukocytosis exceeding 20 × 10^9/L for 13 weeks during pregnancy is uncommon.
- This case details a rare instance of pregnancy-induced leukocytosis.
Observation:
- A 33-year-old woman at 27 weeks gestation developed asymptomatic leukocytosis.
- The condition persisted despite antibiotic treatment until a cesarean section at 40+3 weeks.
- Post-delivery, neutrophil counts normalized within 24 hours.
Findings:
- Pregnancy-induced leukocytosis can be asymptomatic and persistent throughout gestation.
- Resolution of leukocytosis occurred rapidly after delivery.
- The patient and infant showed positive health outcomes at 2-year follow-up.
Implications:
- Pregnancy-induced leukocytosis may be linked to maternal immunoregulation.
- For pregnancies complicated by malignant leukocytosis, delivery is the most effective therapeutic strategy.
- This case underscores the importance of considering pregnancy-specific physiological changes in diagnosing leukocytosis.
Related Concept Videos
01:27Disorders of Leukocytes
1.0K
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
1.0K
01:28Acute Pyelonephritis II: Diagnostic Studies and Management
27
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
27
01:27Acute Pyelonephritis I: Introduction
31
Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such...
31
01:30Classification of Leukocytes
2.2K
Leukocytes are classified into two groups based on the presence or absence of cytoplasmic granules. Granular leukocytes, which contain granules, belong to the myeloid lineage and are divided into three subtypes: neutrophils, eosinophils, and basophils. These cells are roughly spherical and characterized by the granules in their cytoplasm.
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...
2.2K
01:21Structure and Function of Leukocytes
2.2K
An adult in good health typically has between 4,500 and 11,000 leukocytes, or white blood cells, per microliter of blood, which constitutes about 1% of the total blood volume. Unlike red blood cells, white blood cells contain a nucleus and other cellular organelles but do not have hemoglobin. Most white blood cells reside in connective tissues, particularly in lymphatic organs such as the lymph nodes, with only a small fraction present in circulating blood.
White blood cells protect the body...
White blood cells protect the body...
2.2K