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A bibliometric analysis of studies on the gut microbiota in cardiovascular disease from 2004 to 2022
Ming Sheng1, Shuquan Xu2, Wei-Wei Chen3
1Department of Library, Gannan Medical University, Ganzhou, Jiangxi, China.
Insights
Research on the gut microbiota (GM) and cardiovascular disease (CVD) has surged. The USA leads in publications, with emerging research hotspots including short-chain fatty acids and the Mediterranean diet for prevention.
Area of Science:
- Microbiology
- Cardiology
- Bibliometrics
Background:
- Growing evidence links gut microbiota (GM) to cardiovascular disease (CVD).
- Significant research has emerged in the last decade, necessitating a bibliometric analysis.
- A gap exists in understanding the publication landscape and research trends in GM and CVD.
Purpose of the Study:
- To conduct a bibliometric analysis of research on the gut microbiota and cardiovascular disease.
- To identify publication trends, influential countries, institutions, authors, and journals.
- To map the research hotspots and emerging themes in this field.
Main Methods:
- A comprehensive search was conducted on the Web of Science database on September 30, 2022.
- 1,500 articles and reviews on gut microbiota and CVD published between 2004 and 2022 were analyzed.
- Bibliometric analysis was performed using Microsoft Excel, CiteSpace, and VOSviewer software.
Main Results:
- Publication output increased dramatically from 2004 to 2021, with 1,708 total publications identified.
- The USA and China are the leading countries in publications, with significant contributions.
- Key emerging research areas include "short-chain fatty acid," "Mediterranean diet," and "intestinal barrier."
Conclusions:
- Research on gut microbiota and cardiovascular disease has rapidly expanded over the past decade.
- The USA and China are the most influential countries in this research area.
- Future research should focus on emerging hotspots such as short-chain fatty acids, metabolic diseases, and the Mediterranean diet for prevention.
Background:
Increasing evidence indicates that the gut microbiota (GM) is linked to cardiovascular disease (CVD). Many studies on the GM in CVD have been published in the last decade. However, bibliometric analysis in this field is still lacking.
Methods:
On 30 September 2022, a search of the Web of Science™ (WoS; Clarivate™, Philadelphia, PA, USA) yielded 1,500 articles and reviews on the GM and CVD. Microsoft Excel and CiteSpace and VOSviewer software were used to analyze publication trends and research hotspots in this field.
Results:
Our search generated 1,708 publications on the GM in CVD published between 2004 and 2022, and 1,500 articles and review papers were included in the final analysis. The number of publications relating to the GM in CVD increased from 1 in 2004 to 350 in 2021. China (485 publications, 9,728 non-self-citations, and an H-index of 47) and the USA (418 publications, 24,918 non-self-citations, and an H-index of 82) contributed 32.31%, and 27.85%, respectively, of the total number of publications. Examination of the number of publications (Np) and number of citations, excluding self-citations (Nc), of individual authors showed that Y. L. Tian (Np: 18, Nc: 262, and H-index: 12), from China, is the most productive author, followed by R. Knight (Np: 16, Nc: 3,036, and H-index: 15) and M. Nieuwdorp (Np: 16, Nc: 503, and H-index: 9). The Chinese Academy of Medical Sciences and Peking Union Medical College accounted for the largest number of publications (Np: 62, Nc: 3,727, and H-index: 13, average citation number (ACN): 60.11). The journal Nutrients had the most publications (Np: 73, Nc: 2,036, and ACN: 27.89). The emerging keywords in this field were "monooxygenase 3" (strength 3.24, 2020-2022), "short-chain fatty acid" (strength 4.63, 2021-2022), "fatty liver disease" (strength 3.18, 2021-2022), "metabolic disease" (strength 3.04, 2021-2022), "Mediterranean diet" (strength 2.95, 2021-2022), "prevention" (strength 2.77, 2021-2022), and "intestinal barrier" (strength 2.8, 2021-2022).
Conclusion:
Publications on the GM in CVD rapidly increased in the last decade. The USA was the most influential country in publications in this field, followed by China. The journal with the most publications was Nutrients. Monooxygenase-3, short-chain fatty acids, fatty liver disease, metabolic disease, the Mediterranean diet, intestinal barrier, and prevention are the current hotspots or potential hotspots for future study.
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