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Cross-cultural adaptation and validation of the PedsQL™ stem cell transplant module in China: A methodological and
Yuting Wei1, Heng Zhang1, Xiaowen Qian2
1Department of Hematology and Oncology, Children's Hospital of Nanjing Medical University, Nanjing, China.
Insights
This study translated the Pediatric Quality of Life Inventory™ (PedsQL™) Stem Cell Transplant Module into Chinese for pediatric Hematopoietic stem cell transplantation (HSCT) survivors. The Chinese version is a reliable and valid tool for assessing quality of life in these children.
Area of Science:
- Pediatric Oncology
- Health Outcomes Research
- Translational Research
Background:
- Hematopoietic stem cell transplantation (HSCT) has improved survival rates in children.
- There is a need for validated quality of life (QoL) assessment tools for pediatric HSCT patients in China.
- This study addresses the lack of culturally adapted QoL measures for Chinese pediatric HSCT survivors.
Purpose of the Study:
- To translate and culturally adapt the English Pediatric Quality of Life Inventory™ (PedsQL™) Stem Cell Transplant Module into a Chinese mandarin version.
- To evaluate the reliability and validity of the translated Chinese PedsQL™ Stem Cell Transplant Module.
- To provide a tool for assessing QoL in Chinese children undergoing HSCT.
Main Methods:
- The PedsQL™ Stem Cell Transplant Module and PedsQL™ 4.0 Generic Core Scales were administered to 120 children (ages 2-18) and their parents in China.
- Feasibility was assessed by completion rates and missing item percentages.
- Reliability was evaluated using internal consistency (Cronbach's alpha) and test-retest reliability.
- Validity was assessed through factor analysis and correlation analyses.
Main Results:
- The Chinese PedsQL™ Stem Cell Transplant Module demonstrated high feasibility with low item non-response rates.
- Internal consistency (Cronbach's alpha) was ≥0.70 for most dimensions in both child and parent reports.
- Test-retest reliability was good (0.685 for parents, 0.765 for children).
- Factor analysis identified eight underlying factors, explaining 74.54% of the variance.
- Strong correlations were found between the PedsQL™ 4.0 and the Transplant Module scores (0.748 child self-report, 0.808 parent proxy-report).
Conclusions:
- The Chinese mandarin version of the PedsQL™ Stem Cell Transplant Module is a feasible, reliable, and valid instrument.
- This validated tool can effectively assess the quality of life for Chinese children after HSCT.
- The findings support the use of this translated module in clinical practice and research for improved patient care.
Background:
Hematopoietic stem cell transplantation (HSCT), as a mature technology, has significantly improved the survival rate of children. However, there lack efficient scales to assess the quality of life (QoL) of children with HSCT in China, which has important implications in the care of this population. This study aimed to translate the original English Pediatric Quality of Life Inventory™ (PedsQL™) Stem Cell Transplant Module into a Chinese mandarin version, and evaluate its reliability.
Methods:
Children of ages 2-18 years who had received HSCT at Children's Hospital of Nanjing Medical University and Children's Hospital of Fudan University were recruited. Children or their parents were asked to fill the PedsQL™ 4.0 Generic Core Scales, PedsQL™ Stem Cell Transplant Module, and PedsQL™ Family Information Form. Feasibility was evaluated by completion rate and the percentage of missing items, reliability by the internal consistency and test-retest reliability, and validity by factor analysis and correlation analysis between the scores of total scale and each dimension.
Results:
A total of 120 children (mean age 6.37, SD = 3.674) and some parents were included. A low percentage of items were missed in returned reports. Cronbach's alpha coefficient reached 0.70 in the majority of dimensions of both child self-report and parent proxy-report. Test-retest reliability was 0.685 in parents' forms and 0.765 in child's forms. Eight factors were extracted, with a cumulative contribution rate of 74.54%. The correlation between PedsQL™ 4.0 and Transplant Module was 0.748 for children self-report and 0.808 for parent proxy-report.
Conclusions:
This study provides evidence that the Chinese mandarin version of the PedsQL™ Stem Cell Transplant is feasible, reliable and valid in evaluating the QoL of Chinese children after HSCT.
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