Caudatin attenuates inflammatory reaction by suppressing JNK/AP-1/NF-κB/caspase-1 pathways in activated HMC-1 cells

Hee-Yun Kim1, Ho-Geun Kang2, Yu-Jin Choi3

  • 1Asan, 31499 Republic of Korea Biochip Research Center, Hoseo University.

Insights

Caudatin, derived from Cynanchum auriculatum, effectively suppresses mast cell activation and reduces inflammatory cytokines linked to COVID-19 hyperinflammation. This compound may offer a natural approach for managing inflammatory conditions.

Area of Science:

  • Immunology
  • Pharmacology
  • Natural Products

Background:

  • Cytokine storm and mast cell activation contribute to COVID-19 hyperinflammation.
  • Identifying natural compounds to modulate these inflammatory pathways is crucial.

Purpose of the Study:

  • To investigate the anti-inflammatory effects of caudatin on human mast cell line HMC-1.
  • To explore caudatin's potential in mitigating mast cell-mediated inflammation.

Main Methods:

  • HMC-1 cells were treated with varying doses of caudatin.
  • Key signaling molecules including JNK, AP-1, NF-κB, and caspase-1 were analyzed.
  • mRNA expression and protein synthesis of pro-inflammatory cytokines were assessed.

Main Results:

  • Caudatin suppressed JNK, AP-1, and NF-κB activation by inhibiting IκBα phosphorylation.
  • Caudatin reduced activated-caspase-1 levels and inhibited its activation.
  • Non-toxic doses of caudatin decreased pro-inflammatory cytokine mRNA and protein levels.

Conclusions:

  • Caudatin effectively inhibits the JNK/AP-1/NF-κB/caspase-1 signaling pathway in mast cells.
  • Caudatin reduces the secretion of inflammatory cytokines, offering potential therapeutic benefits.
  • Caudatin may serve as a valuable ingredient in functional foods for inflammatory conditions like COVID-19.

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