Related Experiment Video For bipolar disorder
Updated: Aug 13, 2025

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
Published on: November 11, 2016
Circadian rhythm disruptions: A possible link of bipolar disorder and endocrine comorbidities
Xiu Yan1, Peiwei Xu1, Xueli Sun1
1Department of Psychiatry, West China Hospital of Sichuan University, Chengdu, China.
Abstract:
Epidemiological studies have demonstrated an association between bipolar disorder (BP) and endocrine diseases. Further, circadian rhythm disruptions may be a potential common pathophysiological mechanism of both disorders. This review provides a brief overview of the molecular mechanisms of circadian rhythms, as well as roles circadian rhythms play in BP and common endocrine comorbidities such as diabetes and thyroid disease. Treatments targeting the circadian system, both pharmacological and non-pharmacological, are also discussed. The hope is to elicit new interest to the importance of circadian system in BP and offer new entry points and impetus to the development of medicine.
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