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Testosterone Therapy in Advanced Prostate Cancer.

Emily Chedrawe1, Aditya Sathe2, Josh White1

  • 1Department of Urology, Dalhousie University, Halifax, Canada.

Androgens: Clinical Research and Therapeutics
|January 23, 2023
PubMed
Summary
This summary is machine-generated.

Androgen deprivation therapy for advanced prostate cancer (PCa) causes side effects due to low testosterone. This review examines testosterone therapy (TTh) safety in advanced PCa, where evidence is limited.

Keywords:
ADTadvanced prostate cancertestosterone therapy

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Area of Science:

  • Oncology
  • Urology
  • Endocrinology

Background:

  • Androgen deprivation therapy (ADT) is standard for advanced prostate cancer (PCa).
  • ADT causes low testosterone, leading to adverse effects like vasomotor symptoms, sexual dysfunction, and mood changes.
  • Testosterone therapy (TTh) was historically contraindicated in advanced PCa due to concerns of activating cancer growth.

Purpose of the Study:

  • To review the potential implications and safety of testosterone therapy (TTh) in men with advanced prostate cancer (PCa).
  • To define advanced PCa as biochemical recurrence or metastatic disease (hormone-sensitive or castration-resistant).

Main Methods:

  • Literature review of existing studies and publications on TTh in advanced PCa.
  • Analysis of historical contraindications versus recent case reports and inquiries regarding TTh use.

Main Results:

  • Limited evidence exists regarding the safety of TTh in advanced PCa.
  • TTh is considered safe in patients treated for localized PCa, but data for advanced stages is scarce.
  • Despite limited evidence, some men with advanced PCa inquire about and receive TTh.

Conclusions:

  • The safety and efficacy of TTh in advanced PCa remain largely unestablished.
  • Further research is crucial to understand the implications of TTh in this patient population.
  • Clinical decision-making regarding TTh in advanced PCa should consider the current lack of robust evidence.