Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pleural Disorders: Types and Brief Description

Pleural Disorders: Types and Brief Description

The pleura is a vital part of the respiratory system. It's a double-layered membrane surrounding the lungs and lining the chest cavity. The two layers of the pleura are:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Physicians and artificial intelligence diverge in evaluating large language models on real clinical cases.

NPJ digital medicine·2026

Same author

Kernel-based Maximum likelihood reconstruction of attenuation and activity (MLAA) in SPECT imaging for improved attenuation correction and activity quantification: Simulation, phantom and patient validation studies.

Physics in medicine and biology·2026

Same author

Nanomaterial strategies for antibiotic-resistant infections: Mechanistic frameworks, rational design, and clinical translation.

Materials today. Bio·2026

Same author

Reply: Radial Wall Strain and the Stepwise Integration of Physiology and Vulnerability in Revascularization Decision Making.

JACC. Asia·2026

Same author

Cucurbitacin B mitigates <i>Staphylococcus aureus</i> pathogenicity and reprograms macrophage responses to restore host defense.

Journal of pharmaceutical analysis·2026

Same author

Response to Letter Regarding Article, "Interpreting AI noise Driven Radiation Reduction in Coronary Angiography: The Role of Technical and Clinical Determinants".

Circulation. Cardiovascular interventions·2026

Search research articles

Related Experiment Video

Updated: Aug 13, 2025

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Published on: April 21, 2022

Diffuse malignant peritoneal mesothelioma: A review.

Luanbiao Sun¹, Chenguang Li¹, Shuohui Gao¹

¹Gastrointestinal Colorectal and Anal Surgery, China-Japan Union Hospital, Changchun, China.

Frontiers in Surgery

|January 23, 2023

Summary

This summary is machine-generated.

Diffuse malignant peritoneal mesothelioma (DMPM) is a rare cancer. Targeting the PI3K/AKT/mTOR pathway shows promise for new treatments, offering hope for improved patient outcomes.

Keywords:

diffuse malignant peritoneal mesothelioma (DMPM)hyperthermic intraperitoneal chemotherapy (hipec)immunotherapy signaling pathway targeted molecular therapy

More Related Videos

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Published on: December 21, 2019

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model

Published on: October 2, 2015

Related Experiment Videos

Last Updated: Aug 13, 2025

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Published on: April 21, 2022

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Published on: December 21, 2019

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model

Published on: October 2, 2015

Area of Science:

Oncology
Molecular Biology
Surgical Oncology

Background:

Diffuse malignant peritoneal mesothelioma (DMPM) is a rare, aggressive malignancy.
DMPM causes significant morbidity through abdominal complications.
Current treatments are limited, highlighting the need for novel therapeutic strategies.

Purpose of the Study:

To review diagnostic advancements in DMPM.
To explore targeted therapy potential for DMPM.
To discuss the role of signaling pathways in DMPM progression and treatment.

Main Methods:

Review of computed tomography (CT) and immunohistochemical markers (WT1, D2-40, calmodulin, BAP1).
Analysis of the phosphatidylinositol 3-kinase (PI3K)/AKT serine/threonine kinase 1 (AKT)/mammalian target of rapamycin (mTOR) signaling pathway.
Evaluation of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) as standard treatment.

Main Results:

BAP1 expression is a key diagnostic marker for DMPM malignancy.
The PI3K/AKT/mTOR pathway is implicated in DMPM's malignant phenotype.
Combined inhibition of PI3K and mTOR pathways presents a potential therapeutic avenue.

Conclusions:

Novel targeted therapies are crucial for improving DMPM patient prognosis.
Targeting the PI3K/AKT/mTOR pathway offers promising therapeutic potential.
Further research into combined receptor tyrosine kinase inhibition is warranted.