Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Epidemiology of AIDS--statistical analyses.

O J Iversen1, S Engen

  • 1Department of Microbiology, University of Trondheim, Norway.

Journal of Epidemiology and Community Health
|March 1, 1987
PubMed
Summary

Statistical analysis of AIDS epidemiology reveals an average incubation period of 60 months. Approximately 27% of individuals infected with HIV develop AIDS within 8-10 years, indicating significant disease progression.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Estimating Density Dependence, Environmental Variance, and Long-Term Selection on a Stage-Structured Life History.

The American naturalist·2023
Same author

Effective size of density-dependent two-sex populations: the effect of mating systems.

Journal of evolutionary biology·2017
Same author

Estimating fluctuating selection in age-structured populations.

Journal of evolutionary biology·2012
Same author

Optimal foraging: the importance of environmental stochasticity and accuracy in parameter estimation.

The American naturalist·2009
Same author

Environmental stochasticity and extinction risk in a population of a small songbird, the great tit.

The American naturalist·2008
Same author

Estimating density dependence from population time series using demographic theory and life-history data.

The American naturalist·2008

Area of Science:

  • Epidemiology
  • Biostatistics
  • Public Health

Background:

  • Understanding the incubation period and progression of Acquired Immunodeficiency Syndrome (AIDS) is crucial for public health interventions.
  • Transfusion-associated transmission represents a significant route of Human Immunodeficiency Virus (HIV) infection.

Purpose of the Study:

  • To statistically analyze the epidemiology of AIDS, focusing on incubation time and progression rates.
  • To estimate the number of HIV infections resulting from transfusions between 1978 and 1984.

Main Methods:

  • Application of maximum likelihood theory to reported cases of transfusion-associated AIDS.
  • Utilizing data from the San Francisco CDC cohort study for model validation.
  • Developing and applying an incubation time model with a probability factor (p).

Main Results:

  • Estimated mean incubation period for AIDS is approximately 60 months (SD 19 months).
  • A probability factor (p) of 0.27 suggests about 27% of HIV-infected individuals develop AIDS within 8-10 years.
  • An exponential increase in transfusion-associated HIV infections was estimated from 1978-1984, with a 2.74 annual relative increase.

Conclusions:

  • The estimated incubation period and progression rates align with observed AIDS cases.
  • The findings suggest a significant spread of HIV through transfusions during the specified period.
  • Statistical modeling provides valuable insights into disease dynamics and transmission patterns.

Related Experiment Videos