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Updated: Aug 13, 2025

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PPAR agonists for the treatment of primary biliary cholangitis: Old and new tales

Francesca Colapietro1,2, M Eric Gershwin3, Ana Lleo1,2

  • 1Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.

Journal of Translational Autoimmunity
|January 23, 2023
PubMed
Abstract

Keywords:
AEs, adverse eventsAIH, Autoimmune HepatitisALP, Alkaline PhosphataseAMA, Antimitochondrial antibodiesBZF, BezafibrateCKD, chronic kidney diseaseElafibranorFDA, Food and DrugFF, FenofibrateFXR, Farnesoid X ReceptorFibratesGGT, γ-glutamil transferaseHCC, Hepatocellular CarcinomaHDL, high-density lipoproteinHR, Hazard RatioHSC, Hepatic Stellate CellsIL-1β, Interleukin-1IgM, Immunoglobulin MLDL, low-density- lipoproteinLT, Liver TransplantMDR3, multidrug resistance protein 3NASH, Non Alcoholic Steato-HepatitsNRS, Numerical Raing ScaleOCA, Obeticholic AcidOR, Odds RatioPAR, protease-activated receptorsPBC, Primary Biliary CholangitisPC, phosphatidylcholinePH, Portal HypertensionPPAR agonistsPPAR, peroxisome proliferator-activated receptorPrimary biliary cholangitisQoL, Quality of LifeRCT, randomized controlled trialSAE, Severe Adverse EventSaroglitazarSeladelparTGR, transmembrane G protein-coupled receptorTLR, Toll Like ReceptorTNF-α, Tumor Necrosis Factor- αUDCAUDCA, ursodeoxycholic acidUK, United KingdomULN, upper limit of normalVAS, Visual Analogue ScaleVRS, Verbal Rating Scale

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