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Loss of CAMK2G affects intrinsic and motor behavior but has minimal impact on cognitive behavior

Pomme M F Rigter1,2, Charlotte de Konink2,3, Geeske M van Woerden1,2,3

  • 1Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, Netherlands.

Frontiers in Neuroscience
|January 23, 2023
PubMed
Abstract

Insights

Calcium/calmodulin-dependent protein kinase 2 gamma subunit (CAMK2G) is crucial for motor function and neurodevelopment. Loss of CAMK2G impairs innate behaviors, suggesting a unique role in brain development.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • The gamma subunit of calcium/calmodulin-dependent protein kinase 2 (CAMK2G) is expressed in the brain and linked to neurodevelopmental disorders.
  • Limited research exists on CAMK2G's specific functions, with varying roles attributed to different cell types.

Purpose of the Study:

  • To investigate the role of CAMK2G in brain functioning.
  • To perform extensive phenotypic characterization of a Camk2g knockout mouse model.

Main Methods:

  • Generation and phenotypic characterization of a Camk2g knockout mouse.
  • Behavioral analysis, including assessment of learning, synaptic plasticity, motor function, nest-building, and marble burying.

Main Results:

  • Identified distinct spatial expression patterns for different CAMK2G isoforms in the brain.
  • CAMK2G plays a minor role in hippocampus-dependent learning and synaptic plasticity.
  • CAMK2G is essential for motor function, with its absence leading to impaired nest-building and marble burying behaviors.

Conclusions:

  • CAMK2G exhibits a unique function within the brain compared to other CAMK2 isozymes.
  • These findings support the involvement of CAMK2G in neurodevelopmental processes.
Keywords:
Camk2g knockoutbehaviorisoformsneurodevelopmentplasticity

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