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Expansion and Enrichment of Gamma-Delta γδ T Cells from Apheresed Human Product
Published on: September 22, 2021
Biological characteristics of γδT cells and application in tumor immunotherapy
Renhong Zhu1,2, Qian Yan3, Yashu Wang4
1Department of Laboratory Medicine, Second Affiliated Hospital of Shandong First Medical University, Tai'an, China.
Abstract:
Human γδT cells are a special immune cell type which exist in small quantities in the body, do not require processing and presentation for antigen recognition, and have non-major histocompatibility complex (MHC)-restricted immune response. They play an important role in the body's anti-tumor, anti-infection, immune regulation, immune surveillance and maintenance of immune tolerance. This article reviews the generation and development of human γδT cells, genetic characteristics, classification, recognition and role of antigens, and research progress in tumor immunotherapy.
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