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The efficacy of high-flow oxygen versus conventional oxygen for asthma control: a meta-analysis of randomized
Haoyue Deng1,2, Yongpeng He3, Xiaoqin Fu3
1Department of Gastroenterology, Suining First People's Hospital, Suining, Sichuan, China.
Introduction:
The efficacy of high-flow oxygen versus conventional oxygen therapy for asthma control remains controversial.
Aim:
This meta-analysis aims to explore the influence of high-flow oxygen versus conventional oxygen therapy on asthma control.
Material And Methods:
We have searched PubMed, Embase, Web of Science, EBSCO, and Cochrane library databases, and included randomized controlled trials (RCTs) assessing the efficacy of high-flow oxygen versus conventional oxygen therapy for asthma control.
Results:
Four RCTs are included in this meta-analysis. Overall, compared with conventional oxygen therapy for asthma, high-flow oxygen is associated with a significantly lower dyspnoea score (standard mean difference (SMD) = -0.63; 95% confidence interval (CI): -1.08 to -0.17; p = 0.008), but reveals no remarkable influence on PaCO2 (SMD = 0.28; 95% CI: -0.22 to 0.77; p = 0.28), PaO2 (SMD = 0.44; 95% CI: -1.34 to 2.22; p = 0.63), intubation rate (OR = 1.09; 95% CI: 0.15 to 8.21; p = 0.93) or hospital length of stay (SMD = -0.07; 95% CI: -0.41 to 0.27; p = 0.67).
Conclusions:
High-flow oxygen may benefit to reduce/may be more beneficial in reducing the dyspnoea score than conventional oxygen therapy for asthma, but shows no improvement in PaCO2, PaO2, intubation or hospital length of stay.
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