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Spirochetes, unique bacteria in the phylum Spirochaetes, are gram-negative, motile, tightly coiled, slender, and flexible. They inhabit aquatic sediments and animals, with some causing diseases like syphilis. Spirochetes are classified into eight genera based on habitat, pathogenicity, phylogeny, and characteristics.Their distinctive motility arises from endoflagella, located within the cell’s periplasm. These endoflagella anchor at the cell poles and extend along the cell length, encased...
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Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
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Updated: Aug 13, 2025

Author Spotlight: Advancing Syphilis Research — Innovations in Treponema pallidum Cultivation and Genetic Engineering
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Neurosyphilis: The Great Imitator.

Nina Jancar1, Mariana Simões1, Filipa Gonçalves1

  • 1Internal Medicine, Hospital de Santa Maria, Lisbon, PRT.

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|January 23, 2023
PubMed
Summary

Neurosyphilis, a severe central nervous system (CNS) infection from Treponema pallidum, presents diverse symptoms. Early diagnosis and parenteral penicillin treatment are crucial for managing this challenging syphilis complication.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Radiology

Background:

  • Syphilis, caused by Treponema pallidum, is a growing public health concern with varied clinical presentations.
Keywords:
acute confusional stateautoimmune limbic encephalitiscns lesionsneurosyphilisparaneoplastic encephalitis syndromes

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  • Neurosyphilis, a CNS manifestation, can occur at any stage, leading to diverse neurological and psychiatric symptoms.
  • Diagnostic challenges arise from heterogeneous manifestations and the lack of pathognomonic imaging signs.