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Fibronectin-like immunoreactivity in the developing cerebral cortex.

G R Stewart1, A L Pearlman

  • 1Department of Cell Biology, Washington University School of Medicine, St. Louis, Missouri 63110.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|October 1, 1987
PubMed
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Fibronectin, an extracellular matrix glycoprotein, transiently appears in developing mouse brain regions crucial for early neuron migration. This suggests fibronectin aids in guiding axonal growth cones during cortical development.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Extracellular Matrix Research

Background:

  • The developing cerebral cortex relies on precise molecular cues for neuronal organization.
  • Extracellular matrix (ECM) components play critical roles in neural development, including cell migration and axon guidance.

Purpose of the Study:

  • To investigate the temporal and spatial expression pattern of fibronectin in the developing mouse cerebral cortex.
  • To elucidate the potential role of fibronectin in guiding early afferent axons during cortical development.

Main Methods:

  • Immunohistochemical analysis using antibodies against fibronectin (aFN).
  • Microscopic examination of fibronectin distribution in mouse embryonic brains at various developmental stages (E10-E19).

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Main Results:

  • Antifibronectin (aFN) binding showed a distinct pattern, initially localized to blood vessels and pia-arachnoid at E10.
  • Fibronectin immunoreactivity appeared in the neuropil at E11-12, becoming more diffuse in the preplate by E12-13.
  • By E13-14, aFN was detected in the marginal zone and subplate, areas containing early afferents, diminishing by E18-19.

Conclusions:

  • The transient expression of fibronectin in specific cortical zones suggests its role in establishing migratory pathways for early cortical afferents.
  • Fibronectin may function in concert with other ECM molecules like hyaluronectin, glycosaminoglycans, and laminin to guide axonal growth cones.