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06:24
Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
Published on: January 10, 2025
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Liver function in transgender persons: Challenges in the COVID-19 era
Charalampos Milionis1, Ioannis Ilias2, Eftychia Koukkou1
1Department of Endocrinology, Diabetes and Metabolism, Elena Venizelou Hospital, Athens GR-11521, Greece.
World Journal of Clinical Cases
|January 23, 2023
Summary
Gender-affirming hormone therapy can impact liver health in transgender individuals. Careful monitoring is crucial to prevent liver damage, especially during COVID-19 infection.
Area of Science:
- Endocrinology
- Hepatology
- Public Health
Background:
- Transgender individuals undergo hormonal therapy for physical transition.
- Hormonal treatments involve testosterone for trans men and estradiol with anti-androgens for trans women.
- These therapies can potentially cause liver damage.
Purpose of the Study:
- To highlight the risks of liver damage associated with gender-affirming hormonal therapy.
- To emphasize the increased risk of hepatic complications due to the interaction between COVID-19 and hormonal treatments.
- To advocate for vigilant monitoring and care for transgender patients undergoing these treatments.
Main Methods:
- Review of existing literature on hormonal gender-affirming treatments and their hepatotoxic effects.
- Analysis of the impact of COVID-19 on hepatic tissue.
- Discussion of clinical considerations for managing liver health in transgender patients.
Main Results:
- Hormonal cross-sex therapies carry a risk of hepatotoxicity.
- COVID-19 can affect liver health through various mechanisms.
- Combined effects of hormonal therapy and COVID-19 may exacerbate liver damage.
Conclusions:
- Liver integrity is a significant concern in transgender individuals on long-term hormonal therapy.
- Close monitoring, including laboratory tests and clinical observation, is essential.
- The COVID-19 pandemic necessitates special attention to minimize hepatic risks in this population and improve healthcare access.
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