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Author Spotlight: Biological Standardization to Ensure Reproducibility and Harmonization in Research
Published on: August 4, 2023
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Reproducibility and rigor in rheumatology research
Fatima Alnaimat1, Nadia J Sweis2, Jaleel Jerry G Sweis3
1Division of Rheumatology, Department of Medicine, The University of Jordan, Amman, Jordan.
Frontiers in Medicine
|January 23, 2023
Summary
Scientific progress in rheumatology relies on reproducible research. Analysis of real-world clinical data offers a promising alternative to traditional trials, but its use in underserved regions remains unproven.
Area of Science:
- Rheumatology
- Clinical Research
- Scientific Integrity
Background:
- Scientific progress hinges on reproducible experimentation, observation, and peer-reviewed publication.
- Rigor and reproducibility in rheumatology are enhanced by technical/statistical reviews and research integrity training.
- While prospective clinical trials are the gold standard, they face limitations in global applicability due to cost and time.
Purpose of the Study:
- To assess the potential for using real-world clinical data in rheumatology research.
- To explore the feasibility of applying this research paradigm in medically underserved regions.
Main Methods:
- Analysis of real-world patient-centered clinical data from electronic health records, billing reports, and disease registries.
- Evaluation of the applicability of these methods in diverse healthcare settings.
Main Results:
- Real-world data analysis is increasingly utilized for patient outcomes in rheumatology.
- The applicability of this approach in medically underserved regions is currently unknown.
Conclusions:
- Real-world clinical data analysis presents a valuable complement to traditional trials in rheumatology.
- Further investigation is needed to determine the feasibility of this approach in resource-limited settings worldwide.
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