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Updated: Aug 13, 2025

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
Organocatalytic chiral polymeric nanoparticles for asymmetric aldol reaction
Meir Abuaf1, Subhomoy Das1, Yitzhak Mastai1
1Department of Chemistry, Bar-Ilan University Ramat-Gan 5290002 Israel Yitzhak.Mastai@biu.ac.il +972-03738-4053.
Abstract:
Chiral polymeric particles (CPPs) were studied extensively in recent years due to their importance in pharmaceutical applications. Here, nanosized CPPs were synthesized and applied as catalysts for direct asymmetric aldol reaction. The CPPs were prepared by miniemulsion or inverse miniemulsion based on various chiral amino acid derivatives and characterized by dynamic light scattering and scanning electron microscopy. The nanoparticles with spherical structure between 250 and 400 nm and high chiral surface area were used as catalysts in the aldol reaction at room temperature without additional solvent. l-tryptophan gave the highest enantiomeric excess, >86% with similar catalytic performance four times.
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