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Pityriasis Lichenoides Following SARS-CoV-2 Infection/Vaccination.

Aileen M Feschuk1, Maxwell Green2, Nadia Kashetsky1

  • 1Faculty of Medicine, Memorial University of Newfoundland, 300 Prince Philip Dr.Newfoundland & Labrador, St. John's, A1B 3V6 Canada.

Current Dermatology Reports
|January 23, 2023
PubMed
Summary
This summary is machine-generated.

Pityriasis lichenoides (PL) is a rare skin condition that may occur after COVID-19 infection or vaccination. Most patients experienced skin lesion improvement, suggesting a potential association, though causality is not proven.

Keywords:
COVID-19ImmunizationPLCPLEVAPityriasis lichenoidesSARS-CoV-2Vaccination

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Area of Science:

  • Dermatology
  • Infectious Diseases
  • Vaccinology

Background:

  • Pityriasis lichenoides (PL) is a spectrum of dermatological conditions with variable clinical presentations.
  • Cases of PL following SARS-CoV-2 infection and vaccination have been anecdotally reported.
  • A comprehensive review is needed to guide clinical management.

Purpose of the Study:

  • To review and summarize reported cases of pityriasis lichenoides (PL) following SARS-CoV-2 infection or vaccination.
  • To provide insights for clinicians regarding the diagnosis and management of PL in this context.

Main Methods:

  • A systematic search of PubMed, Embase, and Web of Science databases was conducted.
  • Articles reporting cases of PL associated with SARS-CoV-2 infection/vaccination were identified and reviewed.
  • Data on patient demographics, clinical presentation, latency, and treatment outcomes were extracted.

Main Results:

  • Fourteen cases of PL following SARS-CoV-2 infection/vaccination were identified across 13 articles.
  • The majority of cases (64.3%) occurred post-vaccination, predominantly with the Pfizer-BioNTech vaccine.
  • A temporal association was noted, with latency periods ranging from 5 days to 1 month; 85.7% of patients showed significant improvement or resolution.

Conclusions:

  • A temporal association exists between pityriasis lichenoides (PL) and SARS-CoV-2 infection/vaccination, though causality is not established.
  • The risk of developing PL post-SARS-CoV-2 infection/vaccination is likely very low.
  • Clinicians should consider this potential association in diagnosis and management, offering reassurance due to favorable outcomes.