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Updated: Aug 13, 2025

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos
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Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos

Published on: December 13, 2018

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Role of ncRNA in multiple myeloma

Songze Leng1, Huiting Qu1, Xiao Lv1,2

  • 1Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, People's Republic of China.

Biomarkers in Medicine
|January 23, 2023
PubMed

Insights

Non-coding RNAs (ncRNAs) play a critical role in multiple myeloma (MM) progression. Understanding ncRNA dysregulation offers potential for improved MM diagnostics and therapeutics.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Multiple myeloma (MM) is an incurable blood cancer with variable patient prognosis.
  • Genetic abnormalities, including chromosomal variations and gene mutations, are increasingly implicated in MM pathogenesis.
  • Novel prognostic indicators are needed for better MM diagnosis and treatment.

Purpose of the Study:

  • To review recent findings on the role of regulatory non-coding RNAs (ncRNAs) in multiple myeloma.
  • To evaluate the potential of ncRNAs as prognostic biomarkers and therapeutic targets in MM.

Main Methods:

  • Literature review of studies investigating ncRNA expression and function in multiple myeloma.
  • Analysis of ncRNA involvement in gene expression regulation, cell cycle, invasion, and metastasis in MM.

Main Results:

  • Dysregulation of ncRNAs is observed in multiple myeloma.
  • ncRNAs influence key cancer processes such as cell cycle progression and metastasis.
  • Abnormal ncRNA expression is critical for MM development and progression.

Conclusions:

  • Regulatory ncRNAs are significantly involved in the pathogenesis of multiple myeloma.
  • ncRNAs hold promise as valuable biomarkers for MM prognosis and potential therapeutic targets.
Keywords:
circRNAlncRNAmultiple myelomancRNAsncRNA

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