A boronate-affinity magnetic molecularly imprinted polymer for luteolin recognition

Area of Science:

• Materials Science
• Analytical Chemistry
• Polymer Science

Background:

• Luteolin (LTL) is a valuable flavonoid with potential health benefits.
• Efficient and selective extraction methods are crucial for LTL isolation from natural sources.
• Existing methods may lack selectivity, speed, or reusability.

Purpose of the Study:

• To synthesize and characterize 3-carboxyphenylboronic acid (CP)-functionalized amino-modified Fe3O4 (FNC) magnetic molecularly imprinted polymers (FNC@MIPs).
• To evaluate the performance of FNC@MIPs for the selective separation and identification of luteolin (LTL).
• To optimize solid-phase extraction parameters for LTL detection.

Main Methods:

• Synthesis of FNC@MIPs using Fe3O4 nanoparticles and CP functionalization.
• Characterization of FNC@MIPs using FT-IR, SEM, DLS, XPS, XRD, TGA, and VSM.
• Optimization of solid-phase extraction (SPE) parameters and adsorption kinetics studies.

Main Results:

• FNC@MIPs exhibited homogeneous morphology, strong magnetism, and stable reusability.
• Optimized FNC@MIPs achieved a maximum adsorption capacity of 14.26 mg g-1 with an imprinting factor of 3.62.
• Adsorption kinetics followed pseudo-first-order and Langmuir models, indicating monolayer adsorption.
• Successful application in LTL detection in Lonicera japonica Thunb samples with recoveries of 84.5-108.7%.

Conclusions:

• The developed FNC@MIPs provide an effective and selective platform for luteolin extraction and purification.
• This strategy offers a novel approach for the analysis of bioactive compounds in complex matrices.
• The material demonstrates potential for practical applications in natural product chemistry and pharmaceutical analysis.