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Updated: Aug 13, 2025

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
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Telomere Length: Implications for Atherogenesis.

Hao Yin1, J Geoffrey Pickering2,3

  • 1Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, Canada.

Current Atherosclerosis Reports
|January 23, 2023
PubMed
Summary
This summary is machine-generated.

Short leukocyte telomeres are linked to increased risk of atherosclerotic cardiovascular disease. New multi-tissue analyses offer insights into telomere dynamics for improved risk prediction.

Keywords:
AtherosclerosisCoronary diseaseTelomere length

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Area of Science:

  • Cardiovascular Science
  • Genetics
  • Aging Research

Background:

  • Telomere length, a biomarker of cellular aging, has been increasingly studied in relation to cardiovascular diseases.
  • Advances in genomic analysis have expanded methods for telomere length measurement.

Purpose of the Study:

  • To review and synthesize current evidence on the association between telomere length and atherosclerotic ischemic disease.
  • To explore the potential causal relationship and predictive value of telomere length in cardiovascular disease.

Main Methods:

  • Review of recent meta-analyses and large population studies on telomere length and ischemic disease.
  • Application of Mendelian randomization strategies to assess causality.
  • Analysis of multi-tissue telomere length dynamics.

Main Results:

  • Consistent evidence links shorter leukocyte telomeres with increased risk of ischemic disease and cardiovascular mortality.
  • Mendelian randomization studies suggest a causal role for shorter leukocyte telomeres.
  • Interindividual variability highlights the need for multi-tissue analyses for accurate biological aging assessment.

Conclusions:

  • Short leukocyte telomeres are a significant risk factor for atherosclerotic cardiovascular disease.
  • Integrated analysis of telomere lengths across multiple tissues may enhance cardiovascular risk prediction and management strategies.