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Updated: Aug 13, 2025

Author Spotlight: Discovering New Alkaloids in Plants with Advanced Mass Spectrometry Techniques
Published on: March 8, 2024
Two new β-carboline alkaloids from the roots of Anemone altaica
Kun Du1,2, Meng-Nan Zeng1, Yan-Zhi Wang3,4
1School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, China.
Abstract:
Two new β-carboline alkaloids, anemonilins A and B (1-2), and two known β-carboline alkaloids, flazine (3) and 4-(9H-β-carbolin-l-yl)-4-oxo-butyric acid (4), were isolated from the roots of Anemone altaica. The structures of the isolated compounds were elucidated with spectroscopic and spectrometric methods (1D and 2DNMR, HRESIMS). Compounds 2 and 4 significantly attenuated the growth inhibition induced by lipopolysaccharide (LPS) in normal rat kidney tubule epithelioid (NRK52e) cells (p < 0.05 or p < 0.01). Furthermore, compound 2 significantly reduced the apoptosis (p < 0.05) and the caspase-3/9 expression of NRK52e cells induced by LPS.
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