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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

617
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
617
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.0K
Tumor Progression02:07

Tumor Progression

6.4K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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Related Experiment Video

Updated: Aug 13, 2025

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
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[Molecular tumor board and theranostics].

P O Rumyantsev1

  • 1MMC Group of clinics.

Problemy Endokrinologii
|January 23, 2023
PubMed
Summary

Molecular tumor boards (MTBs) are revolutionizing cancer care by integrating genomic data to personalize treatment. This precision oncology approach shows promise for improving patient survival and treatment efficacy in solid tumors.

Area of Science:

  • Oncology
  • Genomics
  • Molecular Biology

Context:

  • Clinical oncology is rapidly evolving with targeted and immunotherapy advancements.
  • Molecular tumor research is crucial for developing precise, effective, and less toxic cancer therapies.
  • Genomic studies and molecular imaging (PET, SPECT) aid in assessing tumor status and selecting optimal treatments.

Purpose:

  • To highlight the increasing need for molecular tumor boards (MTBs) in clinical oncology practice.
  • To discuss the role of molecular profiling in guiding personalized cancer treatment strategies.
  • To emphasize the potential of MTBs in advancing precision oncology.

Summary:

  • Molecular tumor boards (MTBs) integrate genomic and transcriptomic tumor profiles to recommend personalized treatment regimens.

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Related Experiment Videos

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  • Early clinical experience suggests MTB-recommended treatments lead to improved relapse-free and overall survival compared to standard care.
  • Advanced genomic technologies and molecular imaging are integral to the MTB process.

    • Impact:

    • MTBs represent a significant tool for the advancement of precision personalized oncology.
    • Further research, including randomized controlled trials, is needed to solidify evidence-based conclusions.
    • Personalized treatment selection based on molecular profiles has the potential to enhance patient outcomes in solid cancers.