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Pentosan Polysulfate-Associated Dysplasia in Patients With Inflammatory Bowel Disease: A Case Series
Jenna Anderson1, Spencer Frost2, Kian Keyashian2
1Oregon Health & Science University, Department of Medicine, Division of Gastroenterology & Hepatology, Portland, Oregon, USA.
Introduction:
This study evaluates the potential association of pentosan polysulfate (PPS) with inflammatory bowel disease (IBD) or dysplasia.
Methods:
We searched electronic medical records to identify patients with IBD using PPS.
Results:
Ten of 30 identified patients (33.3%) had colonic dysplasia. Six of them (60%) underwent colectomy for endoscopically unresectable dysplasia. Three (10%) discontinued PPS, each with an apparent benefit.
Discussion:
Patients with IBD at 2 institutions who had taken PPS had high rates of colonic dysplasia leading to surgery. Patients who stopped PPS showed improvement in their colitis. PPS may play a causal role in the development of colitis and dysplasia.
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