Related Experiment Videos
Facile synthesis of 2-[(3-aminopropyl)thio]adenosine 5'-diphosphate: a key intermediate for the synthesis of
J R Jefferson1, J B Hunt, G A Jamieson
1American Red Cross Cell Biology Laboratory, Rockville, Maryland 20855.
Journal of Medicinal Chemistry
|November 1, 1987
Abstract:
Adenosine 5'-diphosphate (ADP) and, uniquely, its C-2 derivatized analogues are able to induce platelet activation. We here report the synthesis of 2-[(3-aminopropyl)thio]-ADP from ADP itself via 1,N6-etheno-ADP. 2-[(3-Aminopropyl)thio]-ADP induced platelet aggregation with a potency about one-seventh that of ADP itself and should prove a useful intermediate in the synthesis of other probes of platelet function.