Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cell-based therapies for traumatic optic neuropathy: Recent advances, challenges, and perspectives.

Neural regeneration research·2025
Same author

ROS-Responsive Hydrogel Delivering METRNL Enhances Bone Regeneration via Dual Stem Cell Homing and Vasculogenesis Activation.

Advanced healthcare materials·2025
Same author

Mg-Cross-Linked Alginate Hydrogel Induces BMSC/Macrophage Crosstalk to Enhance Bone Tissue Regeneration via Dual Promotion of the Ligand-Receptor Pairing of the OSM/miR-370-3p-gp130 Signaling Pathway.

ACS applied materials & interfaces·2024
Same author

An immunotherapeutic artificial vitreous body hydrogel to control choroidal melanoma and preserve vision after vitrectomy.

Science advances·2023
Same author

Advances and Prospects in Materials for Craniofacial Bone Reconstruction.

ACS biomaterials science & engineering·2023
Same author

Eyedrop-based macromolecular ophthalmic drug delivery for ocular fundus disease treatment.

Science advances·2023

Related Experiment Video

Updated: Aug 13, 2025

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

9.8K

Thermodynamic 2D Silicene for Sequential and Multistage Bone Regeneration.

Ni Ni1,2, Min Ge3,4, Rui Huang1,2

  • 1Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, P. R. China.

Advanced Healthcare Materials
|January 23, 2023
PubMed
Summary

Engineered nanoparticles (SNSs@AIPH) combined with near-infrared II (NIR-II) light promote bone healing by enhancing cell proliferation, blood vessel growth, and bone formation. This novel biomaterial strategy offers a promising approach for effective bone regeneration in critical-sized defects.

Keywords:
angiogenesisproliferationsequential bone repairsilicenethermodynamics

More Related Videos

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs
10:19

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Published on: August 8, 2022

2.0K
Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering
09:49

Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering

Published on: February 23, 2024

1.9K

Related Experiment Videos

Last Updated: Aug 13, 2025

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

9.8K
Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs
10:19

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Published on: August 8, 2022

2.0K
Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering
09:49

Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering

Published on: February 23, 2024

1.9K

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Nanotechnology

Background:

  • Bone healing is complex, requiring cell recruitment, revascularization, and osteogenic differentiation.
  • Critical-sized bone defects face challenges like insufficient osteoblasts, poor vascularization, and limited bone induction.
  • Current strategies often struggle to address these limitations sequentially and efficiently.

Purpose of the Study:

  • To design and engineer a novel 2D nanomaterial, SiO2-silicene@azobis(imidazolyl propane) (SNSs@AIPH), for sequential and efficient bone repair.
  • To investigate the synergistic effects of SNSs@AIPH and near-infrared II (NIR-II) irradiation on bone healing processes.
  • To evaluate the potential of this bionic-oriented strategy in bone tissue engineering.

Main Methods:

  • Fabrication of 2D SiO2-silicene@azobis(imidazolyl propane) (SNSs@AIPH) nanoparticles.
  • Utilizing controllable NIR-II irradiation to stimulate intracellular reactive oxygen species generation.
  • Assessing the impact on bone marrow mesenchymal stem cells (BMSCs) proliferation, angiogenesis, and osteogenic differentiation in vitro.
  • Evaluating bone repair efficacy in a rat cranial defect model.

Main Results:

  • NIR-II irradiation of SNSs@AIPH significantly accelerated early BMSCs proliferation and angiogenesis.
  • The engineered SNSs@AIPH nanoparticles demonstrated high biocompatibility and promoted BMSCs osteogenic differentiation by activating TGFβ and BMP pathways.
  • In vivo studies showed enhanced BMSCs proliferation and vascularization, followed by significant osteogenic differentiation, leading to effective bone repair in rat cranial defects.

Conclusions:

  • NIR-II-mediated SNSs@AIPH represents a promising bionic-oriented strategy for bone regeneration.
  • This approach effectively addresses key limitations in bone healing, including cell availability, vascularization, and osteoinduction.
  • The study broadens the perspective on applying cell-instructive biomaterials in bone tissue engineering.