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[Clinical trial of the preparation clofazolin used intravenously]
Insights
Chlophazolin effectively lowers blood pressure in hypertensive patients, particularly during crises. Administered intravenously, this preparation offers a significant hypotensive effect lasting over 13 hours in most cases.
Area of Science:
- Pharmacology
- Cardiovascular Medicine
- Clinical Therapeutics
Background:
- Hypertension and hypertensive crises pose significant clinical challenges.
- Intravenous administration of antihypertensive agents is crucial for rapid blood pressure reduction.
Purpose of the Study:
- To evaluate the hypotensive effect of the Bulgarian preparation Chlophazolin administered intravenously.
- To determine the efficacy and duration of Chlophazolin in managing hypertension and hypertensive crises.
Main Methods:
- A study involving 50 patients with various forms of hypertension.
- Intravenous administration of Chlophazolin at a dose of 0.15 mg.
- Monitoring of systolic and diastolic blood pressure in lying and erect positions.
Main Results:
- Chlophazolin demonstrated a marked hypotensive effect, with average systolic pressure decrease of 30-50 mm Hg and diastolic decrease of 10-25 mm Hg.
- The hypotensive effect was more pronounced with higher initial blood pressure values and lasted over 13 hours in most patients.
- Side effects, including orthostatic disturbances and nausea, were observed in 26% of patients. Renal function markers remained unchanged.
Conclusions:
- Intravenous Chlophazolin is effective and expedient for treating hypertensive crises and severe hypertension.
- The preparation provides a sustained hypotensive effect, though duration may vary in patients with very high blood pressure.
- Chlophazolin is well-tolerated, with manageable side effects, and does not impact key renal and electrolyte parameters.
Abstract:
The authors studied the hypotensive effect of the Bulgarian preparation Chlophazolin in ampoules of 0,15 mg, administered i. v. The study covered 50 patients, 44 of them with hypertonic disease II and III stage and the rest (6)--with renal and renovasal hypertension. The i. v. administration of chlophazolin was established to have a marked hypotensive effect and be expedient for the treatment of hypertonic crises and hypertension with high values. In a dose of 0,15 mg i. v. the preparation leads to a sharp decrease in the first 20 min, whereas during the following hours it is kept to lower values: systolic pressure-an average decrease of 30-40 mm Hb in a lying position, to 45-50 mm Hg in an erect position; the diastolic pressure-an average decrease of 10-15 mm Hg in a lying position to 20-25 mm Hg in an erect position. The hypotensive effect is better manifested in higher initial values of the pressure. It lasts approximately more than 13 hours but in 1/5 of the patients, with higher values of blood pressure, its effect is exhausted within 6-8 hours. Side effects of the preparation were registered in 26 per cent of the cases; orthostatic disturbances, sleepiness, dryness of the mouth, nausea. I. v. administration of chlopazolin does not change the excretion of urea and creatinine, diuresis and serum levels of sodium, potassium and chlorine.