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Updated: Aug 13, 2025
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Anti-Nuclear Antibody Screening Using HEp-2 Cells
Published on: June 23, 2014
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[Paraneoplastic syndromes in rheumatology]
Patrick-Pascal Strunz1, Marc Schmalzing2
1Medizinische Klinik und Poliklinik II, Schwerpunkt für Rheumatologie/Klinische Immunologie, Universitätsklinikum Würzburg, Oberdürrbacher Str. 6, 97080, Würzburg, Deutschland.
Zeitschrift Fur Rheumatologie
|January 23, 2023
Summary
Paraneoplastic syndromes are rare rheumatic diseases linked to cancer, aiding early malignancy diagnosis. Their incidence may rise with new cancer treatments, increasing rheumatologist importance.
Area of Science:
- Rheumatology, Oncology
- Rare Diseases
- Malignancy-Associated Conditions
Context:
- Paraneoplastic syndromes involve musculoskeletal symptoms associated with cancer.
- Their recognition is crucial for early cancer detection and prognosis.
- Immune checkpoint inhibitor therapy may be increasing paraneoplastic syndrome incidence and severity.
Purpose:
- To present nine paraneoplastic syndromes with their clinical manifestations.
- To provide a diagnostic algorithm for tumor detection in these cases.
- To emphasize the importance of treating the underlying malignancy.
Summary:
- Discusses nine paraneoplastic syndromes, including paraneoplastic arthritis, cancer-associated myositis, and hypertrophic osteoarthropathy.
- Highlights characteristic clinical features and a diagnostic algorithm for tumor detection.
- Notes that treating the primary cancer is key, as conventional treatments often yield poor results.
Impact:
- Enhances understanding of rare rheumatic diseases linked to cancer.
- Aids rheumatologists in early diagnosis of malignancies.
- Informs treatment strategies, emphasizing oncologic management over symptomatic relief.
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