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The potential use of mesenchymal stem cells-derived exosomes as microRNAs delivery systems in different diseases

Elham Oveili1, Somayeh Vafaei2, Haniyeh Bazavar3

  • 1Department of Pharmaceutical Science, Azad Islamic University of Medical Sciences, Tehran, Iran.

Cell Communication and Signaling : CCS
|January 23, 2023
PubMed

Insights

Mesenchymal stem cell-derived exosomes (MSC-EXOs) show promise as natural carriers for delivering microRNAs (miRNAs) to target cells. Their unique properties make them ideal for therapeutic applications in various diseases.

Area of Science:

  • Biomedical Engineering
  • Molecular Biology
  • Cell Biology

Background:

  • MicroRNAs (miRNAs) are key regulators of gene expression, with altered levels implicated in numerous diseases like cancer and neurodegenerative disorders.
  • Therapeutic strategies involve modulating miRNA function using anti-miRNAs or miRNA mimetics.
  • Exosomes (EXOs), particularly those derived from mesenchymal stem cells (MSCs), are emerging as efficient and safe natural carriers for biomolecules.

Discussion:

  • Mesenchymal stem cell-derived exosomes (MSC-EXOs) possess inherent immune-privileged, tumor-homing, and adaptable characteristics.
  • Their potential as drug delivery vehicles is being explored for targeted delivery of therapeutic agents.
  • This review focuses on the production, purification, and miRNA loading techniques for MSC-EXOs.

Key Insights:

  • MSC-EXOs offer a promising platform for miRNA-based therapeutics due to their biological properties.
  • Methods for MSC-EXO production, isolation, and miRNA loading are crucial for therapeutic efficacy.
  • Modification of MSC-EXOs can enhance targeted delivery of miRNAs for disease treatment.

Outlook:

  • Further research into optimizing MSC-EXO production and miRNA loading is essential for clinical translation.
  • Investigating modified MSC-EXOs for targeted delivery in specific disease contexts will advance therapeutic development.
  • MSC-EXOs hold significant potential for next-generation miRNA-based therapies.
Keywords:
Drug delivery systemExosomesMesenchymal stem cellsNon-coding RNA

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