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Study protocol: an observational study of distress, immune function and persistent pain in HIV
Victoria J Madden1,2, Ncumisa Msolo3, Luyanduthando Mqadi3,2
1Pain Research Team, Department of Anaesthesia and Perioperative Medicine, Neuroscience Institute, University of Cape Town, Cape Town, South Africa torymadden@gmail.com.
BMJ Open
|January 24, 2023
Summary
This study investigates how psychological distress and inflammatory responses affect pain in people with HIV. Findings may reveal new pathways linking distress, inflammation, and persistent pain.
Area of Science:
- Neuroimmunology
- Pain Medicine
- HIV Research
Background:
- Persistent pain and distress are common in people with HIV.
- The bidirectional relationship between distress and pain is established, but underlying mechanisms require elucidation.
- Inflammatory reactivity (IR) may mediate how distress exacerbates pain via neuroimmune pathways.
Purpose of the Study:
- To characterize relationships between distress, IR, pain signaling (secondary hyperalgesia), and pain in people with HIV.
- To investigate if IR mediates the link between distress and persistent pain.
- To explore the association between IR and pain signaling.
Main Methods:
- Prospective, observational, case-control study of 100 people with HIV over 6 months.
- Assessed distress, IR (post-LPS challenge), and pain (persistent pain).
- Measured secondary hyperalgesia in a subsample; employed mediation analysis and generalized mixed effects models.
Main Results:
- This section is not available in the provided abstract.
- This section is not available in the provided abstract.
- This section is not available in the provided abstract.
Conclusions:
- This section is not available in the provided abstract.
- This section is not available in the provided abstract.
- This section is not available in the provided abstract.
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