Related Experiment Video

Updated: Aug 13, 2025

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
07:30

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

10.1K

Clinical Characteristics and Associated Factors for Infection and in-Hospital Mortality in Inpatients with

Minxi Lao1,2, Hui Ouyang3, Nannan Li1

  • 1Department of Rheumatology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China.

Infection and Drug Resistance
|January 24, 2023
PubMed
Abstract

Insights

Infections are common early complications in polymyositis/dermatomyositis (PM/DM), leading to high in-hospital mortality. Older age, interstitial lung disease, and recurrent infections predict poor outcomes.

Area of Science:

  • Rheumatology
  • Infectious Diseases
  • Clinical Medicine

Background:

  • Polymyositis/dermatomyositis (PM/DM) is an autoimmune disease affecting muscles and skin.
  • Infection is a significant concern for patients with PM/DM, impacting prognosis.

Purpose of the Study:

  • To investigate the clinical characteristics of infections in a southern Chinese cohort of PM/DM patients.
  • To identify factors associated with in-hospital mortality in these patients.

Main Methods:

  • Retrospective review of clinical data from 554 PM/DM patients (2015-2022).
  • Multivariate logistic regression analysis to determine factors for infection and mortality.

Main Results:

  • 35.6% of patients experienced infections, predominantly bacterial and affecting the lungs.
  • Anti-MDA5 positive patients had more severe infections and higher mortality.
  • In-hospital mortality was 6.5%, with infection being the leading cause of death.

Conclusions:

  • Infections are early, frequent complications in PM/DM, often involving the lungs and caused by Gram-negative bacteria.
  • Infection is a primary driver of in-hospital mortality in PM/DM.
  • Older age, interstitial lung disease, and multiple infection episodes are linked to worse prognosis.
Keywords:
MDA5dermatomyositisinfectionmortalitypolymyositis

More Related Videos

Author Spotlight: Advancing Pathogen Detection and Disease Assessment in Real-Time Using M-ROSE03:22

Author Spotlight: Advancing Pathogen Detection and Disease Assessment in Real-Time Using M-ROSE

Published on: March 1, 2024

501
Author Spotlight: An Effective Traditional Chinese Medicinal Treatment for Chronic Obstructive Pulmonary Disease with Abdominal Distension05:19

Author Spotlight: An Effective Traditional Chinese Medicinal Treatment for Chronic Obstructive Pulmonary Disease with Abdominal Distension

Published on: September 1, 2023

1.5K

Related Concept Videos

Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
18
Pericarditis II: Clinical Features and Diagnostic Tests01:19

Pericarditis II: Clinical Features and Diagnostic Tests

Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
17
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
18
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
13
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.1K
Myocarditis IV: Nursing Management01:22

Myocarditis IV: Nursing Management

Myocarditis is an inflammatory condition of the myocardium requiring meticulous nursing management for optimal patient outcomes. Effective management begins with a thorough assessment of the patient's medical history, paying close attention to past infections, autoimmune disorders, travel history, and exposure to toxins or drugs. Recent viral infections and systemic diseases are particularly relevant due to their potential role in triggering myocarditis.Physical Examination and MonitoringThe...
17