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Progress and prospects toward supramolecular bioactive ion transporters
Abhishek Mondal1, Manzoor Ahmad1,2, Debashis Mondal1,3
1Chemistry Department, Indian Institute of Science Education and Research Pune, Dr. Homi Bhabha Road, Pashan, Pune 411008, Maharashtra, India. ptalukdar@iiserpune.ac.in.
Chemical Communications (Cambridge, England)
|January 24, 2023
Summary
Artificial ion transporters offer new hope for treating diseases like cystic fibrosis and cancer. This review highlights advancements in designing these systems for improved biocompatibility and targeted therapies.
Area of Science:
- Biochemistry
- Biophysics
- Materials Science
Background:
- Cellular processes rely on natural ion channels for selective ion transport and osmolality balance.
- Dysfunctional ion channels due to genetic mutations or structural changes can lead to severe diseases, including cystic fibrosis.
- Artificial ion transport systems are emerging as a therapeutic strategy for channel replacement therapy.
Purpose of the Study:
- To review recent progress in the design and development of artificial chloride ion transporters.
- To discuss the effects of these artificial systems on biological systems.
- To highlight future directions for novel ion transporters with enhanced biocompatibility and anti-cancer properties.
Main Methods:
- Review of literature on artificial ion transporter design and development.
- Analysis of studies investigating the biological effects of artificial ion transporters.
- Discussion of stimuli-responsive systems for targeted therapeutic applications.
Main Results:
- Artificial ion transport systems show promise in replacing dysfunctional natural channels and treating genetic disorders.
- These systems have demonstrated potential in selectively killing cancer cells.
- Stimuli-responsive artificial ion transporters offer enhanced target specificity.
Conclusions:
- Artificial ion transporters represent a significant advancement in channel replacement therapy and cancer treatment.
- Further development is needed to improve biocompatibility and anti-cancer efficacy.
- Stimuli-responsive designs are key to advancing clinical applications of artificial ion transporters.
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