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Published on: February 11, 2022
Surgical Treatment of Constrictive Pericarditis
Brunella Bertazzo1, Alejandro Cicolini1, Martin Fanilla2
1Favaloro Foundation University Hospital Department of Cardiac Surgery Intensive Care Buenos Aires Argentina Department of Cardiac Surgery Intensive Care, Favaloro Foundation University Hospital, Buenos Aires, Argentina.
Insights
Pericardiectomy for constrictive pericarditis shows significant benefits, especially for patients with preserved functional class. Early intervention is recommended to improve outcomes and reduce prolonged hospital stays.
Area of Science:
- Cardiology
- Thoracic Surgery
- Internal Medicine
Background:
- Constrictive pericarditis treatment primarily involves pericardiectomy.
- Surgery carries risks of high early morbidity, mortality, and limited long-term survival.
Purpose of the Study:
- To describe the outcomes of pericardiectomies performed over a 30-year period.
- To identify factors associated with prolonged hospitalization and mortality after pericardiectomy.
Main Methods:
- A retrospective, observational study of 45 pericardiectomies performed between 1992 and 2022.
- Analysis of patient demographics, preoperative conditions, and surgical outcomes.
Main Results:
- Idiopathic constrictive pericarditis was most common (46.6%).
- Advanced functional class, persistent pleural effusion, and symptom onset >6 months were linked to prolonged hospitalization.
- In-hospital and 30-day mortality rates were 6.6% and 8.8%, respectively.
- Patients with preserved functional class had a 17-fold increased likelihood of symptom improvement.
Conclusions:
- Advanced functional class and delayed symptom onset (>6 months) are poor prognostic indicators for pericardiectomy.
- Early surgical intervention is strongly supported to improve patient outcomes and reduce hospitalization duration.
Introduction:
The mainstay of the treatment of constrictive pericarditis is pericardiectomy. However, surgery is associated with high early morbidity and mortality and low long-term survival. The aim of this study is to describe our series of pericardiectomies performed over 30 years.
Methods:
A descriptive, observational, and retrospective analysis of all pericardiectomies performed at the Institute of Cardiology and Cardiovascular Surgery of the Favaloro Foundation was performed.
Results:
A total of 45 patients underwent pericardiectomy between June 1992 and June 2022, mean age was 52 years (standard deviation ± 13.9 years), and 73.3% were men. Idiopathic constrictive pericarditis was the most prevalent (46.6%). The variables significantly associated with prolonged hospitalization were preoperative advanced functional class (incidence of 38.4%, P<0.04), persistent pleural effusion (incidence of 81.8%, P<0.01), and although there was no statistical significance with the use of cardiopulmonary bypass, a trend in this association is evident (P<0.07). We found that 100% of the patients with an onset of symptoms greater than six months had a prolonged hospital stay. In-hospital mortality was 6.6%, and 30-day mortality was 8.8%. The preserved functional class is 17 times more likely to improve their symptomatology after pericardiectomy (odds ratio 17, 95% confidence interval 2.66-71; P<0.05).
Conclusion:
Advanced functional class at the time of pericardiectomy is the variable most strongly associated with mortality and prolonged hospitalization. Onset of the symptoms greater than six months is also a poor prognostic factor mainly associated with prolonged hospitalization; based on these data, we strongly support the recommendation of early intervention.
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