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Related Concept Videos

Interference and Decay01:16

Interference and Decay

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Forgetting is a complex cognitive phenomenon influenced by several factors, among which interference and decay are particularly prominent. These processes explain why individuals often struggle to retrieve specific information from memory, leading to lapses in recall that can be observed in everyday situations.
Interference occurs when competing memories hinder the retrieval of particular information. It can be classified into two types: proactive and retroactive interference. Proactive...
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Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
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Forgetting is an intrinsic aspect of human memory, characterized by the gradual loss or inaccessibility of information over time. Hermann Ebbinghaus, a pioneering psychologist, extensively studied this phenomenon and formulated the forgetting curve. This curve illustrates that memory loss occurs rapidly immediately after learning and then decelerates over time. Several mechanisms contribute to forgetting, including encoding failure, storage decay, retrieval failure, and interference.
Encoding...
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Fatigue01:21

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Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
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Long-term Potentiation01:25

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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Spatial remapping in the subicular complex and entorhinal cortex follows low-dimensional geometric principles.

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Author Spotlight: Advancing Diabetes Research with Static Exercise Training in Mice
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Use it or lose it.

Ohad Rechnitz1,2, Dori Derdikman1

  • 1Ruth and Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.

Elife
|January 24, 2023
PubMed
Summary
This summary is machine-generated.

Blocking memory center neuron activity causes cell death, potentially explaining Alzheimer's disease disorientation. This finding offers new insights into neurodegenerative mechanisms.

Area of Science:

  • Neuroscience
  • Pathology

Background:

  • Alzheimer's disease is characterized by cognitive decline, including spatiotemporal disorientation.
  • The precise mechanisms underlying neuronal dysfunction and loss in Alzheimer's remain under investigation.
Keywords:
Alzheimer's diseaseactivity-dependent competitionchemogenetic silencingcircuit plasticityentorhinal cortexmouseneuroscienceselective vulnerability

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