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[Multiple loci account for human height].

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  • 1Biologiste, généticien et immunologiste, Président d'Aprogène (Association pour la promotion de la Génomique), 13007 Marseille, France.

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Genetic studies combining 281 GWAS analyses identified 12,111 SNPs in 7,209 loci for adult height. This resolves the "missing heritability" issue, revealing functionally relevant genetic determinants.

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Area of Science:

  • Human genetics
  • Quantitative trait loci analysis
  • Genome-wide association studies

Context:

  • Adult height is a complex human trait influenced by numerous genetic factors.
  • Previous genome-wide association studies (GWAS) identified many genetic loci but could not fully explain the heritability of height, leading to the concept of "missing heritability".

Purpose:

  • To identify the full spectrum of single nucleotide polymorphisms (SNPs) associated with adult height.
  • To determine if identified genetic loci are functionally relevant.
  • To assess the contribution of identified SNPs to the overall heritability of adult height.

Summary:

  • A meta-analysis of 281 genome-wide association studies (GWAS) identified 12,111 significant SNPs located in 7,209 distinct loci associated with adult height.
  • These identified SNPs collectively account for nearly all of the SNP-based heritability of adult height.
  • The study concludes that the "missing heritability" for adult height has been resolved and that the identified loci are functionally relevant.

Impact:

  • This comprehensive genetic analysis resolves the "missing heritability" paradox for adult height.
  • The findings provide a complete picture of the genetic architecture of adult height.
  • The methodology serves as a powerful model for future genetic studies of complex diseases and traits.