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Published on: July 5, 2017
Grape Seed Components as Protectors of Inflammation, DNA Damage, and Cancer
Melissa Mancini1, Maria Eduarda Vieira Cerny1, Natali Silva Cardoso1
1Cytogenetics and Genome Stability Laboratory, University Hospital and Pharmacy Postgraduate Program, Federal University of Santa Catarina, Florianópolis, Brazil.
Purpose Of Review:
Oxidative stress is related to the pathogenesis of several chronic diseases, including inflammatory processes. Free radicals excess increase not only oxidative stress but also genomic instability. Polyphenols are non-enzymatic antioxidants that act as a defense barrier against free radicals and non-radical oxidants. The purpose of this article was to review published articles relating dietary polyphenols contained in grape seed proanthocyanidin extracts with its potential for reversing DNA damage.
Recent Findings:
Proanthocyanidin components exert pleiotropic actions having several biological, biochemical, and significant pharmacological effects and showed the ability to reduce cytotoxicity and genotoxicity. Grape seed proanthocyanidin extracts showed the ability to reduce cytotoxicity and genotoxicity through the comet assay and the micronucleus technique.
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