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[Pharmacokinetics of cefpiramide concentration in lung tissues]
T Ikeda1, T Sakai, Y Nishimura
1Department of Surgery, Tokyo Metropolitan Komagome Hospital.
Abstract:
Concentrations of cefpiramide (CPM) in human lung tissues were determined after 1 g intravenous bolus injection in 6 patients with lung tumors and pyothorax. Concentrations of the CPM in blood and lung tissues were determined and analyzed pharmacokinetically. Levels of CPM in the lung tissues reached 38.4 micrograms/g at 2 hours and declined to 27.7 micrograms/g in 6 hours. Levels of CPM in the lung tissues were higher than 50% of those in the serum between 100 minutes and 360 minutes after the administration of CPM.
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