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Related Experiment Videos

[Thyroid dysfunction following external irradiation of the neck].

N Hayabuchi1, K Jingu, K Masuda

  • 1Dept. of Radiology, Kyushu Univ. Hospital.

Gan No Rinsho. Japan Journal of Cancer Clinics
|August 1, 1987
PubMed
Summary

Radiation therapy for neck cancers, particularly malignant lymphomas, can lead to thyroid dysfunction. Higher radiation doses correlate with increased thyroid-stimulating hormone (TSH) elevation, necessitating monitoring and potential thyroid hormone replacement.

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[Reirradiation with brachytherapy for recurrent tongue cancer after initial brachytherapy].

Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica·2001

Area of Science:

  • Endocrinology
  • Oncology
  • Radiation Oncology

Context:

  • Assesses thyroid function in patients undergoing neck radiation therapy.
  • Focuses on a cohort of 120 patients, predominantly those with malignant lymphomas (110 patients).
  • Investigates subclinical thyroid dysfunction despite the absence of overt clinical symptoms.

Purpose:

  • To evaluate the incidence and dose-dependency of thyroid dysfunction following neck radiation.
  • To determine the impact of radiation dosage on thyroid-stimulating hormone (TSH) levels.
  • To explore the influence of lymphangiography and chemotherapy on thyroid function.

Summary:

  • Thyroid function tests revealed TSH elevation in 24% to 47% of patients receiving 30 Gy or more of radiation to the entire neck.

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  • No patients presented with clinical symptoms of thyroid dysfunction.
  • Nine patients required thyroid hormone supplementation based on functional test results.
  • The study also considered the effects of lymphangiography and systemic combination chemotherapy.

    • Impact:

    • Highlights the risk of subclinical hypothyroidism after neck radiation, particularly with higher doses.
    • Underscores the importance of regular thyroid function monitoring in cancer survivors treated with neck radiotherapy.
    • Provides data to inform clinical management strategies for thyroid health in this patient population.